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As a result, researchers have investigated the effectiveness of L-arginine in the treatment of severe wounds and tissue waste in serious illnesses.

Nitric oxide acts to widen blood vessels in the blood stream, which may help aid certain circulatory conditions. People also get additional L-arginine as part of their regular diet.

Red meats, fish, dairy, and eggs all contain low amounts of L-arginine that help the body to replenish its necessary resources. This is often true for older adults or people with certain medical conditions. In these cases, people may be prescribed artificial L-arginine in the form of oral medication, injections, or creams.

Several potential health conditions may benefit from an increased intake of L-arginine. Some people take L-arginine as a supplement. As with any supplement, a person should use it with caution. Although L-arginine is considered safe in moderate doses, too much L-arginine can have severe side effects, including death. It is important to understand how the supplement may interact with the body and with additional medications before taking it. These effects give L-arginine an array of potential benefits that range from heart health and chest pain to helping to build muscles, repair wounds, and improve male fertility.

Although there are many claims about the benefits of L-Arginine, not all of them are supported by scientific research studies. Additionally, L-arginine may have the potential to help with many other issues. There are several additional areas that researchers are interested in exploring regarding L-arginine and its effects on the human body. Products and services. Thank you for Subscribing Our Housecall e-newsletter will keep you up-to-date on the latest health information.

Please try again. Something went wrong on our side, please try again. Show references L-arginine. Natural Medicines. Accessed Dec. Arginine hydrochloride. IBM Micromedex. Mayo Clinic Press Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. ART Home L-arginine. Twinlab L-Arginine. Vitacost L- Arginine HCl. Make sure the L-arginine supplement you take passed our test and is right for you! Isn't your health worth it? See the Review Now Already a member?

Join now at www. Summary What is L-arginine? L-arginine or arginine is an amino acid which is necessary for the body's production of nitric oxide, a compound that relaxes blood vessels and allows more blood to flow through arteries. The form in supplements is typically "free form" arginine, but is sometimes a compound, such as L-arginine HCl. See What It Is. Not all labels clearly list the amount of arginine. See What to Consider When Buying , but you can use the Results table to easily compare amounts of arginine in tested supplements.

What are the health benefits of L-arginine? L-arginine may modestly improve symptoms, such as exercise intolerance, in congestive heart failure, angina, and leg pain due to intermittent claudication, as well as exercise endurance in recreational and older athletes. Some, but not all, studies have shown some modest benefits in sexual dysfunction and Raynaud's syndrome See What It Does.

How much L-arginine to take? Dosage depends on the condition being treated, but is typically several thousand milligrams per day See Dosage. Best L-arginine products? Among the products that passed our laboratory tests See What CL Found , we selected Top Picks for arginine for general use, cardiovascular, sexual enhancement, and sport.

L-arginine safety and side effects: L-arginine supplementation appears to be generally safe and well tolerated in healthy individuals, although stomach upset may occur and capsules have been reported to irritate the esophagus — so be sure to take with water. L-arginine may interact with blood-pressure lowering and diabetes medications. Do not use if you have had a heart attack, and do not use to treat serious conditions including congestive heart failure, angina, or intermittent claudication without physician supervision.

For details, see Concerns and Cautions. You must be a ConsumerLab. You'll get results for 18 L-arginine supplements: ten selected by ConsumerLab. L-arginine can cause a number of side effects including indigestion, nausea, headache, bloating, diarrhea, gout, blood abnormalities, allergies, airway inflammation, worsening of asthma symptoms, decreased insulin sensitivity , and low blood pressure.

Higher doses of L-arginine can increase stomach acid, so it may also worsen heartburn, ulcers, or digestive upset caused by medications. In addition, L-arginine may aggravate symptoms in people with herpes. L-arginine may interact with certain medications, such as blood pressure medication, diabetes medication, or drugs used to treat erectile dysfunction. If you have diabetes or heart disease, avoid taking L-arginine. Some studies have found that chronic L-arginine supplementation may decrease insulin sensitivity, while others have found no effect or increased insulin sensitivity.

As with many other supplements, L-arginine hasn't been tested for safety in pregnant women, nursing mothers, children, and those with medical conditions or who are taking medications.

There is no standard recommended dose of L-arginine. The appropriate dose for you may depend on factors including your age, gender, and medical history.

Various doses of L-arginine have been studied in research investigating its effect on different conditions. For example, for chest pain, a dose of grams three times per day for up to one month has been used. For erectile dysfunction, a dose of five grams per day has been used. And in studies investigating high blood pressure, a dose of grams per day for weeks has been used. Speak to your healthcare provider to get personalized advice.

In most cases, the body maintains an adequate supply of L-arginine on its own. However, severe burns, infections, and injuries can deplete the body's supply of arginine. Under these conditions, it is necessary to ensure proper intake to meet the increased demands. L-arginine is found in foods that you consume, including red meat, poultry, fish, lentils, and dairy products. Consider adding more chicken, turkey, lean cuts of beef, soybeans, pumpkin seeds, peanuts, lentils, lobster, shrimp, spinach or seaweed to your diet.

Due to evolving research on the relationship between L-arginine and heart disease , avoid taking L-arginine supplements unless you have consulted your healthcare provider first about the possible benefits and risks.

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